GYNEC EXPERT

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What is Non Invasive

Prenatal Screening Test

(NIPT) ?

What conditions are

screened in NextGen NIPT

& NextGen NIPT Advanced?

What is the right time to

opt for NIPT?

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PPV and NPV for the conditions

screened by NextGen NIPT?

Indications for NIPT?

Any time after 10 weeks’ gestational age, NIPT can

be offered to the patient for singleton pregnancy

and twin pregnancy. In case of vanishing twin

pregnancies, there should be 8 weeks gap

between vanishing event and sample collection.

NextGen NIPT

screens for the

following conditions:

NextGen NIPT

Advanced screens for:

3 Common Aneuploidies:

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5 Sex Chromosome Aneuploidies:

Trisomy 21 (Down Syndrome)

Trisomy 18 (Edwards’ Syndrome)

Trisomy 13 (Patau Syndrome)

Note: Sex chromosome abnormalities are not reported

in Twin Pregnancies and Vanishing Twin Pregnancies.

Note : Aneuploidies including monosomy and

trisomy of chromosomes other than Trisomy 13, 18, 21

are called Rare Autosomal Aneuploidies (RAA).

Accuracy for RAA is lower than common

trisomies.

Advanced

Maternal

Age1,2,3

Abnormal

USG or presence

of soft markers

on USG

suggestive of

common

aneuploidies

Recurrent

Pregnancy

Loss

affected

pregnancy1

High risk /

intermediate

risk on maternal

screening test

PPV

>99.99%

94.44%

95.83%

97.78%

99.98%

>99.99%

99.98%

98.73%

(93.15%-99.97%)

>99.99%

(89.72%-100%)

>99.99%

(85.18%-100%)

97.78%

(88.23%-99.94%)

>99.99%

(93.15%-100%)

99.97%

(99.88%-100%)

99.98%

(99.91%-100%)

99.98%

(99.9%-100%)

NPV

SENSITIVITY

(95% CI)

SPECIFICITY

(95% CI)

T21

T18

T13

SCAs

CONDITIONS

PPV - Positive Predictive Value NPV - Negative Predictive Value

SCAs - Sex Chromosomal Aneuploidies

NIPT is a non-invasive and accurate

chromosomal aneuploidy screening test

which is available as early as 10 weeks of

pregnancy.

It is a safe and simple blood test with highest

detection rate (amongst screening tests)

wherein the cell free fetal DNA, circulating in

maternal plasma is tested for common

chromosomal aneuploidies.

This test decreases the chances of procedure

related risk of abortion in expectant mothers.

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